Textbook on Pediatric Clinical Pharmacology

A Textbook of Clinical Pharmacology

The early part focuses on differentiating organic brain disease from psychoses, the importance of reversable brain disease in the elderly and the part the emergency physician has in making this diagnosis. The authors must be commended for the amount of space given to these topics in such a short book. Other points stressed in this part of the book are, not to label patients with behavioural pro...

Pediatric Clinical Pharmacology - ReadingSample

The advances in developmental pharmacokinetics during the past decade reside with an enhanced understanding of the influence of growth and development on drug absorption, distribution, metabolism, and excretion (ADME). However, significant information gaps remain with respect to our ability to characterize the impact of ontogeny on the activity of important drug metabolizing enzymes, transporte...

Pediatric Clinical Pharmacology - Preamble

TEXTBOOK of RECEPTOR PHARMACOLOGY

Clinical pharmacology of cefotaxime in pediatric patients.

Cefotaxime is a new cephalosporin with a spectrum of activity which may make it appropriate for use in pediatric patients. In 33 infants and children, administration of cefotaxime resulted in cure or improvement in 97% of patients, with eradication of 94% of isolated pathogens. Toxicity was minimal. The disposition of cefotaxime in this age group was similar to that reported for adults, with an...